Ontology highlight
ABSTRACT:
SUBMITTER: Goswami M
PROVIDER: S-EPMC5743200 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Goswami Manibarsha M Wilke Kaelyn E KE Carlson Erin E EE
Journal of medicinal chemistry 20171003 19
Bacterial histidine kinases (HKs) are quintessential regulatory enzymes found ubiquitously in bacteria. Apart from their regulatory roles, they are also involved in the production of virulence factors and conferring resistance to various antibiotics in pathogenic microbes. We have previously reported compounds that inhibit multiple HKs by targeting the conserved catalytic and ATP-binding (CA) domain. Herein, we conduct a detailed structure-activity relationship assessment of adenine-based inhibi ...[more]