Ontology highlight
ABSTRACT:
SUBMITTER: Kastenhuber ER
PROVIDER: S-EPMC5743327 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative transcriptional program that touches upon a bewildering array of biological responses. Despite the many unveiled facets of the p53 network, a clear appreciation of how and in what contexts p53 exerts its diverse effects remains unclear. How can we interpret p53's disparate activities and the consequences of its dysfun ...[more]