Ontology highlight
ABSTRACT:
SUBMITTER: Besser RR
PROVIDER: S-EPMC5743464 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Theranostics 20180101 1
Through the use of stem cell-derived cardiac myocytes, tissue-engineered human myocardial constructs are poised for modeling normal and diseased physiology of the heart, as well as discovery of novel drugs and therapeutic targets in a human relevant manner. This review highlights the recent bioengineering efforts to recapitulate microenvironmental cues to further the maturation state of newly differentiated cardiac myocytes. These techniques include long-term culture, co-culture, exposure to mec ...[more]