CDKN2B is critical for verapamil-mediated reversal of doxorubicin resistance in hepatocellular carcinoma.
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ABSTRACT:
SUBMITTER: Zhang T
PROVIDER: S-EPMC5746364 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
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CDKN2B is critical for verapamil-mediated reversal of doxorubicin resistance in hepatocellular carcinoma.
Zhang Tengyue T Ma Kelong K Huang Jin J Wang Shitang S Liu Yabei Y Fan Gaofei G Liu Miao M Yang Guangshan G Wang Cheng C Fan Pingsheng P
Oncotarget 20171026 66
In this study, we explored the function and mechanism of CDKN2B genes in verapamil (VER)-induced reversal of resistance to doxorubicin (ADM) chemotherapy in hepatocellular carcinoma (HCC). We examined 4 HCC cell lines and found that the expression levels of CDKN2B genes correlated with the level of apoptosis induced by ADM+VER. Overexpression of CDKN2B genes promoted apoptosis in cells treated with VER+ADM. CDKN2B knockdown using siRNA weakened the effect of ADM+VER, indicating that ADM+VER prom ...[more]
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