Ontology highlight
ABSTRACT:
SUBMITTER: Waldera-Lupa DM
PROVIDER: S-EPMC5746369 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Waldera-Lupa Daniel Michael DM Etemad-Parishanzadeh Omid O Brocksieper Mareike M Kirchgaessler Nina N Seidel Sabine S Kowalski Thomas T Montesinos-Rongen Manuel M Deckert Martina M Schlegel Uwe U Stühler Kai K
Oncotarget 20171124 66
Primary central nervous system lymphomas (PCNSLs) are mature B-cell lymphomas confined to the central nervous system (CNS). Blood-brain barrier (BBB) dysfunction drastically alters the cerebrospinal fluid (CSF) proteome in PCNSL patients. To reveal the interaction of PCNSL tumors with CNS structures and the vasculature, we conducted a whole-proteome analysis of CSF from PCNSL patients (<i>n</i> = 17 at initial diagnosis) and tumor-free controls (<i>n</i> = 10) using label-free quantitative mass ...[more]