Ontology highlight
ABSTRACT:
SUBMITTER: Yang D
PROVIDER: S-EPMC5746393 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Yang Daming D Hou Tieying T Li Lei L Chu Yimin Y Zhou Fengli F Xu Ying Y Hou Xinyu X Song Huan H Zhu Kai K Hou Zhaoyuan Z Peng Haixia H Jia Hao H
Oncotarget 20171130 66
SMAD family member 1 (Smad1) have been involved in metastatic progression of many cancer types. However, the detailed molecular signalling pathway underlying the regulatory link between Smad1 and metastasis remains elusive. Here, we demonstrate that Smad1 promotes migration of colorectal cancer (CRC) cells by inducing Snail and Ajuba expression simultaneously, but no apparent effect on Twist1 expression. Remarkably, E-cadherin, the best known Snail/Ajuba target gene is downregulated by Smad1 exp ...[more]