Extracellular ATP Activates the NLRP3 Inflammasome and Is an Early Danger Signal of Skin Allograft Rejection.
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ABSTRACT:
SUBMITTER: Amores-Iniesta J
PROVIDER: S-EPMC5746605 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Extracellular ATP Activates the NLRP3 Inflammasome and Is an Early Danger Signal of Skin Allograft Rejection.
Amores-Iniesta Joaquín J Barberà-Cremades Maria M Martínez Carlos M CM Pons José A JA Revilla-Nuin Beatriz B Martínez-Alarcón Laura L Di Virgilio Francesco F Parrilla Pascual P Baroja-Mazo Alberto A Pelegrín Pablo P
Cell reports 20171201 12
Immune cells are equipped with a number of receptors that recognize sterile injury and pathogens. We find that host immune cells release ATP as an inflammatory signal in response to allogeneic transplantation. ATP then acts via a feedback mechanism on the P2X7 channel to activate the NLRP3 inflammasome and subsequently process and release interleukin (IL)-18. This process is a necessary stage in the deleterious Th1 response against allotransplantation via interferon-γ production. Lack of IL-18 r ...[more]
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