Ontology highlight
ABSTRACT:
SUBMITTER: Rossol M
PROVIDER: S-EPMC3535422 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Rossol Manuela M Pierer Matthias M Raulien Nora N Quandt Dagmar D Meusch Undine U Rothe Kathrin K Schubert Kristin K Schöneberg Torsten T Schaefer Michael M Krügel Ute U Smajilovic Sanela S Bräuner-Osborne Hans H Baerwald Christoph C Wagner Ulf U
Nature communications 20120101
Activation of the NLRP3 inflammasome enables monocytes and macrophages to release high levels of interleukin-1β during inflammatory responses. Concentrations of extracellular calcium can increase at sites of infection, inflammation or cell activation. Here we show that increased extracellular calcium activates the NLRP3 inflammasome via stimulation of G protein-coupled calcium sensing receptors. Activation is mediated by signalling through the calcium-sensing receptor and GPRC6A via the phosphat ...[more]