DotAligner: identification and clustering of RNA structure motifs.
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ABSTRACT:
SUBMITTER: Smith MA
PROVIDER: S-EPMC5747123 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
DotAligner: identification and clustering of RNA structure motifs.
Smith Martin A MA Seemann Stefan E SE Quek Xiu Cheng XC Mattick John S JS
Genome biology 20171228 1
The diversity of processed transcripts in eukaryotic genomes poses a challenge for the classification of their biological functions. Sparse sequence conservation in non-coding sequences and the unreliable nature of RNA structure predictions further exacerbate this conundrum. Here, we describe a computational method, DotAligner, for the unsupervised discovery and classification of homologous RNA structure motifs from a set of sequences of interest. Our approach outperforms comparable algorithms a ...[more]
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