Ontology highlight
ABSTRACT:
SUBMITTER: Mann SI
PROVIDER: S-EPMC5747327 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Mann Samuel I SI Heinisch Tillmann T Ward Thomas R TR Borovik A S AS
Journal of the American Chemical Society 20171115 48
Copper-hydroperoxido species (Cu<sup>II</sup>-OOH) have been proposed to be key intermediates in biological and synthetic oxidations. Using biotin-streptavidin (Sav) technology, artificial copper proteins have been developed to stabilize a Cu<sup>II</sup>-OOH complex in solution and in crystallo. Stability is achieved because the Sav host provides a local environment around the Cu-OOH that includes a network of hydrogen bonds to the hydroperoxido ligand. Systematic deletions of individual hydrog ...[more]