Ontology highlight
ABSTRACT:
SUBMITTER: Gu X
PROVIDER: S-EPMC5747364 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Gu Xin X Orozco Jose M JM Saxton Robert A RA Saxton Robert A RA Condon Kendall J KJ Liu Grace Y GY Krawczyk Patrycja A PA Scaria Sonia M SM Harper J Wade JW Gygi Steven P SP Sabatini David M DM
Science (New York, N.Y.) 20171101 6364
mTOR complex 1 (mTORC1) regulates cell growth and metabolism in response to multiple environmental cues. Nutrients signal via the Rag guanosine triphosphatases (GTPases) to promote the localization of mTORC1 to the lysosomal surface, its site of activation. We identified SAMTOR, a previously uncharacterized protein, which inhibits mTORC1 signaling by interacting with GATOR1, the GTPase activating protein (GAP) for RagA/B. We found that the methyl donor <i>S</i>-adenosylmethionine (SAM) disrupts ...[more]