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Current advances in circulating inflammatory biomarkers in atherosclerosis and related cardio-cerebrovascular diseases.


ABSTRACT: Atherosclerosis (AS) is a systemic chronic disease affecting both the coronary and cerebral arteries. Inflammation plays a key role in the initiation and progression of AS, and numerous inflammatory factors have been proposed as potential biomarkers. This article reviews recent research in studies on major circulating inflammatory biomarkers to identify surrogates that may reflect processes associated with AS development and the risk of AS-related vascular events, such as Von Willebrand factor, lectin-like oxidized low-density-lipoprotein receptor-1, soluble urokinase plasminogen activator receptor, regulated upon activation, normal T-cell expressed and secreted, and microparticles, which may provide new perspectives for clinical AS evaluation and risk stratification.

SUBMITTER: Lv JX 

PROVIDER: S-EPMC5747494 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Current advances in circulating inflammatory biomarkers in atherosclerosis and related cardio-cerebrovascular diseases.

Lv Jun-Xuan JX   Kong Qi Q   Ma Xin X  

Chronic diseases and translational medicine 20171126 4


Atherosclerosis (AS) is a systemic chronic disease affecting both the coronary and cerebral arteries. Inflammation plays a key role in the initiation and progression of AS, and numerous inflammatory factors have been proposed as potential biomarkers. This article reviews recent research in studies on major circulating inflammatory biomarkers to identify surrogates that may reflect processes associated with AS development and the risk of AS-related vascular events, such as Von Willebrand factor,  ...[more]

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