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Relationship of thoracic fat depots with coronary atherosclerosis and circulating inflammatory biomarkers.


ABSTRACT: The aim of the study was to determine the relationship of various thoracic fat depots with the presence and extent of coronary artery plaque and circulating biomarkers.In 342 patients (52?±?11 years, 61% male, BMI 29.1?±?5.9 kg/m(2) ) with coronary computed tomography (CT), angiography, we measured the fat volume in four thoracic depots (pericoronary, epicardial, periaortic, extracardiac), assessed coronary plaque, and determined the circulating levels of C-reactive protein, tumor necrosis factor alpha, plasminogen activator inhibitor-1, monocyte chemoattractant protein-1, and adiponectin. The extent of coronary plaque was classified into three groups: 0, 1-3, and >3 segments.Patients with plaque (n =169, 49%) had higher volumes of all four fat depots as compared to patients without plaque (all P?

SUBMITTER: Maurovich-Horvat P 

PROVIDER: S-EPMC4446160 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Relationship of thoracic fat depots with coronary atherosclerosis and circulating inflammatory biomarkers.

Maurovich-Horvat Pál P   Kallianos Kimberly K   Engel Leif-Christopher LC   Szymonifka Jackie J   Schlett Christopher L CL   Koenig Wolfgang W   Hoffmann Udo U   Truong Quynh A QA  

Obesity (Silver Spring, Md.) 20150509 6


<h4>Objective</h4>The aim of the study was to determine the relationship of various thoracic fat depots with the presence and extent of coronary artery plaque and circulating biomarkers.<h4>Methods</h4>In 342 patients (52 ± 11 years, 61% male, BMI 29.1 ± 5.9 kg/m(2) ) with coronary computed tomography (CT), angiography, we measured the fat volume in four thoracic depots (pericoronary, epicardial, periaortic, extracardiac), assessed coronary plaque, and determined the circulating levels of C-reac  ...[more]

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2023-11-09 | GSE237983 | GEO