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The Spatial Relationship between Apparent Diffusion Coefficient and Standardized Uptake Value of 18F-Fluorodeoxyglucose Has a Crucial Influence on the Numeric Correlation of Both Parameters in PET/MRI of Lung Tumors.


ABSTRACT: The minimum apparent diffusion coefficient (ADCmin) derived from diffusion-weighted MRI (DW-MRI) and the maximum standardized uptake value (SUVmax) of FDG-PET are markers of aggressiveness in lung cancer. The numeric correlation of the two parameters has been extensively studied, but their spatial interplay is not well understood. After FDG-PET and DW-MRI coregistration, values and location of ADCmin- and SUVmax-voxels were analyzed. The upper limit of the 95% confidence interval for registration accuracy of sequential PET/MRI was 12?mm, and the mean distance (D) between ADCmin- and SUVmax-voxels was 14.0?mm (average of two readers). Spatial mismatch (D > 12?mm) between ADCmin and SUVmax was found in 9/25 patients. A considerable number of mismatch cases (65%) was also seen in a control group that underwent simultaneous PET/MRI. In the entire patient cohort, no statistically significant correlation between SUVmax and ADCmin was seen, while a moderate negative linear relationship (r = -0.5) between SUVmax and ADCmin was observed in tumors with a spatial match (D ? 12?mm). In conclusion, spatial mismatch between ADCmin and SUVmax is found in a considerable percentage of patients. The spatial connection of the two parameters SUVmax and ADCmin has a crucial influence on their numeric correlation.

SUBMITTER: Sauter AW 

PROVIDER: S-EPMC5748125 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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The Spatial Relationship between Apparent Diffusion Coefficient and Standardized Uptake Value of <sup>18</sup>F-Fluorodeoxyglucose Has a Crucial Influence on the Numeric Correlation of Both Parameters in PET/MRI of Lung Tumors.

Sauter Alexander W AW   Stieltjes Bram B   Weikert Thomas T   Gatidis Sergios S   Wiese Mark M   Klarhöfer Markus M   Wild Damian D   Lardinois Didier D   Bremerich Jens J   Sommer Gregor G  

Contrast media & molecular imaging 20171217


The minimum apparent diffusion coefficient (ADC<sub>min</sub>) derived from diffusion-weighted MRI (DW-MRI) and the maximum standardized uptake value (SUV<sub>max</sub>) of FDG-PET are markers of aggressiveness in lung cancer. The numeric correlation of the two parameters has been extensively studied, but their spatial interplay is not well understood. After FDG-PET and DW-MRI coregistration, values and location of ADC<sub>min</sub>- and SUV<sub>max</sub>-voxels were analyzed. The upper limit of  ...[more]

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