Ontology highlight
ABSTRACT:
SUBMITTER: Silver J
PROVIDER: S-EPMC5748855 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Silver Jared J Zuo Teng T Chaudhary Neha N Kumari Rupa R Tong Pei P Giguere Sophie S Granato Alessandra A Donthula Rakesh R Devereaux Colby C Wesemann Duane R DR
The Journal of experimental medicine 20171215 1
Two immunoglobulin (Ig) diversification mechanisms collaborate to provide protective humoral immunity. Combinatorial assembly of <i>IgH</i> and <i>IgL V</i> region exons from gene segments generates preimmune Ig repertoires, expressed as B cell receptors (BCRs). Secondary diversification occurs when <i>Ig V</i> regions undergo somatic hypermutation (SHM) and affinity-based selection toward antigen in activated germinal center (GC) B cells. Secondary diversification is thought to only ripen the a ...[more]