Ontology highlight
ABSTRACT:
SUBMITTER: Swaminathan M
PROVIDER: S-EPMC5748899 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Swaminathan Madhav M Stafford-Smith Mark M Chertow Glenn M GM Warnock David G DG Paragamian Viken V Brenner Robert M RM Lellouche François F Fox-Robichaud Alison A Atta Mohamed G MG Melby Spencer S Mehta Ravindra L RL Wald Ron R Verma Subodh S Mazer C David CD
Journal of the American Society of Nephrology : JASN 20171016 1
AKI after cardiac surgery remains strongly associated with mortality and lacks effective treatment or prevention. Preclinical studies suggest that cell-based interventions may influence functional recovery. We conducted a phase 2, randomized, double-blind, placebo-controlled trial in 27 centers across North America to determine the safety and efficacy of allogeneic human mesenchymal stem cells (MSCs) in reducing the time to recovery from AKI after cardiac surgery. We randomized 156 adult subject ...[more]