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Mesenchymal stem cells and cardiac repair.

ABSTRACT: Accumulating clinical and experimental evidence indicates that mesenchymal stem cells (MSCs) are promising cell types in the treatment of cardiac dysfunction. They may trigger production of reparative growth factors, replace damaged cells and create an environment that favours endogenous cardiac repair. However, identifying mechanisms which regulate the role of MSCs in cardiac repair is still at work. To achieve the maximal clinical benefits, ex vivo manipulation can further enhance MSC therapeutic potential. This review focuses on the mechanism of MSCs in cardiac repair, with emphasis on ex vivo manipulation.

SUBMITTER: Nesselmann C

PROVIDER: S-EPMC4506151 | biostudies-other | 2008 Oct

REPOSITORIES: biostudies-other

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Mesenchymal stem cells and cardiac repair.

Nesselmann Catharina C Ma Nan N Bieback Karen K Wagner Wolfgang W Ho Anthony A Konttinen Yrjö T YT Zhang Hao H Hinescu Mihail E ME Steinhoff Gustav G

Journal of cellular and molecular medicine 20080805 5B

Accumulating clinical and experimental evidence indicates that mesenchymal stem cells (MSCs) are promising cell types in the treatment of cardiac dysfunction. They may trigger production of reparative growth factors, replace damaged cells and create an environment that favours endogenous cardiac repair. However, identifying mechanisms which regulate the role of MSCs in cardiac repair is still at work. To achieve the maximal clinical benefits, ex vivo manipulation can further enhance MSC therapeu ...[more]

PMID: 18684237

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