Ontology highlight
ABSTRACT:
SUBMITTER: Shoag J
PROVIDER: S-EPMC5749531 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20171204 1
Nearly 50% of prostate cancers harbor gene fusions that lead to overexpression of the transcription factor ERG, while a mutually exclusive 10% of prostate cancers harbor recurrent mutations in the gene encoding the E3 ubiquitin ligase SPOP. Recent reports suggest that SPOP acts as a ubiquitin ligase for ERG and propose that ERG stabilization is the oncogenic effector of SPOP mutation. Here, we used human prostate cancer samples and showed that the vast majority of human SPOP-mutant cancers do no ...[more]