Ontology highlight
ABSTRACT:
SUBMITTER: Bernasocchi T
PROVIDER: S-EPMC7854732 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Nature communications 20210202 1
Driver genes with a mutually exclusive mutation pattern across tumor genomes are thought to have overlapping roles in tumorigenesis. In contrast, we show here that mutually exclusive prostate cancer driver alterations involving the ERG transcription factor and the ubiquitin ligase adaptor SPOP are synthetic sick. At the molecular level, the incompatible cancer pathways are driven by opposing functions in SPOP. ERG upregulates wild type SPOP to dampen androgen receptor (AR) signaling and sustain ...[more]