Ontology highlight
ABSTRACT:
SUBMITTER: Varricchi G
PROVIDER: S-EPMC5749653 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Varricchi Gilda G Galdiero Maria Rosaria MR Loffredo Stefania S Lucarini Valeria V Marone Giancarlo G Mattei Fabrizio F Marone Gianni G Schiavoni Giovanna G
Oncoimmunology 20171113 2
Prolonged low-grade inflammation or smoldering inflammation is a hallmark of a cancer. Eosinophils are components of the immune microenvironment that modulates tumor initiation and progression. Although canonically associated with a detrimental role in allergic disorders, these cells can induce a protective immune response against helminthes, viral and bacterial pathogens. Eosinophils are a source of anti-tumorigenic (e.g., TNF-α, granzyme, cationic proteins, and IL-18) and protumorigenic molecu ...[more]