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Construction of a junction DNA nanostructure and modulation of the junction switching to quadruplexes.

ABSTRACT: A junction DNA nanostructure has been successfully built in lithium acetate buffer solution at a near-neutral pH value through the connection of two slipped junction structures that are formed by G-rich and C-rich strands. The GC-rich duplex junctions in the nanostructure can be switched to G-quadruplexes and i-motifs in weakly acidic potassium acetate solution, which leads to the assembly of DNA nanostructures composed of alternating quadruplex and duplex DNA structures. The transformation between different DNA nanoarchitectures may be applied to the operation of 'DNA nanomachines'.

SUBMITTER: Cao Y

PROVIDER: S-EPMC5750025 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Construction of a junction DNA nanostructure and modulation of the junction switching to quadruplexes.

Cao Yanwei Y Xiang Xiaoxuan X Pei Renjun R Li Yang Y Yan Yuting Y Guo Xinhua X

Royal Society open science 20171220 12

A junction DNA nanostructure has been successfully built in lithium acetate buffer solution at a near-neutral pH value through the connection of two slipped junction structures that are formed by G-rich and C-rich strands. The GC-rich duplex junctions in the nanostructure can be switched to G-quadruplexes and i-motifs in weakly acidic potassium acetate solution, which leads to the assembly of DNA nanostructures composed of alternating quadruplex and duplex DNA structures. The transformation betw ...[more]

PMID: 29308258

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