Ontology highlight
ABSTRACT:
SUBMITTER: Schubert M
PROVIDER: S-EPMC5750219 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Schubert Michael M Klinger Bertram B Klünemann Martina M Sieber Anja A Uhlitz Florian F Sauer Sascha S Garnett Mathew J MJ Blüthgen Nils N Saez-Rodriguez Julio J
Nature communications 20180102 1
Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug research. A common approach is to infer signaling activity of pathways from gene expression. However, mapping gene expression to pathway components disregards the effect of post-translational modifications, and downstream signatures represent very specific experimental conditions. Here we present PROGENy, a method that overcomes both limitations by leveraging a large compendium of publicly available perturba ...[more]