Ontology highlight
ABSTRACT:
SUBMITTER: Earl DC
PROVIDER: S-EPMC5750220 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Earl David C DC Ferrell P Brent PB Leelatian Nalin N Froese Jordan T JT Reisman Benjamin J BJ Irish Jonathan M JM Bachmann Brian O BO
Nature communications 20180102 1
Discovering bioactive metabolites within a metabolome is challenging because there is generally little foreknowledge of metabolite molecular and cell-targeting activities. Here, single-cell response profiles and primary human tissue comprise a response platform used to discover novel microbial metabolites with cell-type-selective effector properties in untargeted metabolomic inventories. Metabolites display diverse effector mechanisms, including targeting protein synthesis, cell cycle status, DN ...[more]