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Progress of genome-wide association studies of ankylosing spondylitis.

ABSTRACT: Ankylosing spondylitis (AS) is an immune-mediated arthritis which primarily affects the spine and sacroiliac joints. Significant progress has been made in discovery of genetic associations with AS by genome-wide association studies (GWAS) over past decade. These findings have uncovered novel pathways involved pathogenesis of the disease and have led to introduction of novel therapeutic treatments for AS. In this Review, we discuss the genetic variations associated with AS identified by GWAS, the major pathways revealed by these AS-associated variations and critical cell types involved in AS development.

SUBMITTER: Li Z

PROVIDER: S-EPMC5750450 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Progress of genome-wide association studies of ankylosing spondylitis.

Li Zhixiu Z Brown Matthew A MA

Clinical & translational immunology 20171201 12

Ankylosing spondylitis (AS) is an immune-mediated arthritis which primarily affects the spine and sacroiliac joints. Significant progress has been made in discovery of genetic associations with AS by genome-wide association studies (GWAS) over past decade. These findings have uncovered novel pathways involved pathogenesis of the disease and have led to introduction of novel therapeutic treatments for AS. In this Review, we discuss the genetic variations associated with AS identified by GWAS, the ...[more]

PMID: 29333268

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