Ontology highlight
ABSTRACT:
SUBMITTER: McEneny-King A
PROVIDER: S-EPMC5750653 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
McEneny-King Alanna A Chelle Pierre P Henrard Severine S Hermans Cedric C Iorio Alfonso A Edginton Andrea N AN
Pharmaceutics 20171017 4
The total body weight-based dosing strategy currently used in the prophylactic treatment of hemophilia A may not be appropriate for all populations. The assumptions that guide weight-based dosing are not valid in overweight and obese populations, resulting in overdosing and ineffective resource utilization. We explored different weight metrics including lean body weight, ideal body weight, and adjusted body weight to determine an alternative dosing strategy that is both safe and resource-efficie ...[more]