Ontology highlight
ABSTRACT:
SUBMITTER: Abou Daher A
PROVIDER: S-EPMC5751131 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Abou Daher Alaa A El Jalkh Tatiana T Eid Assaad A AA Fornoni Alessia A Marples Brian B Zeidan Youssef H YH
International journal of molecular sciences 20171125 12
Sphingolipids, long thought to be passive components of biological membranes with merely a structural role, have proved throughout the past decade to be major players in the pathogenesis of many human diseases. The study and characterization of several genetic disorders like Fabry's and Tay Sachs, where sphingolipid metabolism is disrupted, leading to a systemic array of clinical symptoms, have indeed helped elucidate and appreciate the importance of sphingolipids and their metabolites as active ...[more]