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The Immunogenetics of Psoriasis and Implications for Drug Repositioning.

ABSTRACT: Psoriasis is a genetically-regulated, T lymphocyte-mediated autoimmune skin disease that causes systemic damage, seriously affecting patient quality of life and survival. Psoriasis treatments, which aim to control the disease's development, are greatly limited because its etiology and pathogenesis have not yet been fully elucidated. A large number of studies have demonstrated that immunogenetic elements are the most important factors responsible for psoriasis susceptibility. This paper delineates the immunogenetic mechanisms of psoriasis and provides useful information with regards to performing drug repositioning for the treatment of psoriasis.

SUBMITTER: Xu X

PROVIDER: S-EPMC5751252 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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The Immunogenetics of Psoriasis and Implications for Drug Repositioning.

Xu Xuan X Zhang Hong-Yu HY

International journal of molecular sciences 20171208 12

Psoriasis is a genetically-regulated, T lymphocyte-mediated autoimmune skin disease that causes systemic damage, seriously affecting patient quality of life and survival. Psoriasis treatments, which aim to control the disease's development, are greatly limited because its etiology and pathogenesis have not yet been fully elucidated. A large number of studies have demonstrated that immunogenetic elements are the most important factors responsible for psoriasis susceptibility. This paper delineate ...[more]

PMID: 29292715

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