Dataset Information

Biopersistence of NiO and TiO? Nanoparticles Following Intratracheal Instillation and Inhalation.

ABSTRACT: The hazards of various types of nanoparticles with high functionality have not been fully assessed. We investigated the usefulness of biopersistence as a hazard indicator of nanoparticles by performing inhalation and intratracheal instillation studies and comparing the biopersistence of two nanoparticles with different toxicities: NiO and TiO? nanoparticles with high and low toxicity among nanoparticles, respectively. In the 4-week inhalation studies, the average exposure concentrations were 0.32 and 1.65 mg/m³ for NiO, and 0.50 and 1.84 mg/m³ for TiO?. In the instillation studies, 0.2 and 1.0 mg of NiO nanoparticles and 0.2, 0.36, and 1.0 mg of TiO? were dispersed in 0.4 mL water and instilled to rats. After the exposure, the lung burden in each of five rats was determined by Inductively Coupled Plasma-Atomic Emission Spectrometer (ICP-AES) from 3 days to 3 months for inhalation studies and to 6 months for instillation studies. In both the inhalation and instillation studies, NiO nanoparticles persisted for longer in the lung compared with TiO? nanoparticles, and the calculated biological half times (BHTs) of the NiO nanoparticles was longer than that of the TiO? nanoparticles. Biopersistence also correlated with histopathological changes, inflammatory response, and other biomarkers in bronchoalveolar lavage fluid (BALF) after the exposure to nanoparticles. These results suggested that the biopersistence is a good indicator of the hazards of nanoparticles.

SUBMITTER: Oyabu T

PROVIDER: S-EPMC5751356 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Biopersistence of NiO and TiO₂ Nanoparticles Following Intratracheal Instillation and Inhalation.

Oyabu Takako T Myojo Toshihiko T Lee Byeong-Woo BW Okada Takami T Izumi Hiroto H Yoshiura Yukiko Y Tomonaga Taisuke T Li Yun-Shan YS Kawai Kazuaki K Shimada Manabu M Kubo Masaru M Yamamoto Kazuhiro K Kawaguchi Kenji K Sasaki Takeshi T Morimoto Yasuo Y

International journal of molecular sciences 20171219 12

The hazards of various types of nanoparticles with high functionality have not been fully assessed. We investigated the usefulness of biopersistence as a hazard indicator of nanoparticles by performing inhalation and intratracheal instillation studies and comparing the biopersistence of two nanoparticles with different toxicities: NiO and TiO₂ nanoparticles with high and low toxicity among nanoparticles, respectively. In the 4-week inhalation studies, the average exposure concentrations were 0.3 ...[more]

PMID: 29257061

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Dataset Information

Biopersistence of NiO and TiO? Nanoparticles Following Intratracheal Instillation and Inhalation.

Publications

Biopersistence of NiO and TiO₂ Nanoparticles Following Intratracheal Instillation and Inhalation.

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