Ontology highlight
ABSTRACT:
SUBMITTER: Yagiz K
PROVIDER: S-EPMC5751967 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Yagiz Kader K Rodriguez-Aguirre Maria E ME Lopez Espinoza Fernando F Montellano Tiffany T TT Mendoza Daniel D Mitchell Leah A LA Ibanez Carlos E CE Kasahara Noriyuki N Gruber Harry E HE Jolly Douglas J DJ Robbins Joan M JM
Molecular therapy oncolytics 20171205
Treatment of tumors with Toca 511, a gamma retroviral replicating vector encoding cytosine deaminase, followed by 5-fluorocytosine (5-FC) kills tumors by local production of 5-fluorouracil (5-FU). In brain tumor models, this treatment induces systemic anti-tumor immune responses and long-term immune-mediated survival. Phase 1 Toca 511 and Toca FC (extended-release 5-FC) clinical trials in patients with recurrent high-grade glioma show durable complete responses and promising survival data compar ...[more]