Ontology highlight
ABSTRACT:
SUBMITTER: Cao C
PROVIDER: S-EPMC5752375 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Cao Chike C Ren Yinshi Y Barnett Adam S AS Mirando Anthony J AJ Rouse Douglas D Mun Se Hwan SH Park-Min Kyung-Hyun KH McNulty Amy L AL Guilak Farshid F Karner Courtney M CM Hilton Matthew J MJ Pitt Geoffrey S GS
JCI insight 20171116 22
While the prevalence of osteoporosis is growing rapidly with population aging, therapeutic options remain limited. Here, we identify potentially novel roles for CaV1.2 L-type voltage-gated Ca2+ channels in osteogenesis and exploit a transgenic gain-of-function mutant CaV1.2 to stem bone loss in ovariectomized female mice. We show that endogenous CaV1.2 is expressed in developing bone within proliferating chondrocytes and osteoblasts. Using primary BM stromal cell (BMSC) cultures, we found that C ...[more]