Waist circumference is correlated with poorer cognition in elderly type 2 diabetes women.

ABSTRACT: Waist circumference is associated with type 2 diabetes (T2D) and cognition, yet the relationship between waist circumference and cognition in individuals with T2D is not well understood.We studied the relationship of waist circumference with five cognitive outcomes (executive functioning, language/semantic categorization, attention/working memory, episodic memory, and an overall cognition measure) in 845 cognitively normal elderly with type 2 diabetes (T2D).In women, waist circumference was correlated with significantly lower language and/or semantic categorization performance (P < .0001), executive functioning (P = .026), and overall cognition (P = .003) after controlling for age, education, BMI, and cardiovascular, diabetes-related, APOE ?4, and inflammatory potential confounders. Attention/working memory (P = .532) and episodic memory (P = .144) were not associated with waist circumference. These correlations were not found in men.These results suggest that central adiposity in elderly women with T2D may increase their risk for dementia.

SUBMITTER: West RK 

PROVIDER: S-EPMC5753411 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature