Dataset Information

Waist circumference is genetically correlated with incident Type 2 diabetes in Mexican-American families.

ABSTRACT: We aimed to determine the genetic and environmental correlation between various anthropometric indexes and incident Type 2 diabetes with a focus on waist circumference.We used the data on extended Mexican-American families (808 subjects, 7617.92 person-years follow-up) from the San Antonio Family Heart Study and estimated the genetic and environmental correlations of 16 anthropometric indexes with the genetic liability of incident Type 2 diabetes. We performed bivariate trait analyses using the solar software package.All 16 anthropometric indexes were significantly heritable (range of heritabilities 0.24-0.99). Thirteen indexes were found to have significant environmental correlation with the liability of incident Type 2 diabetes. In contrast, only anthropometric indexes consisting of waist circumference (waist circumference, waist-hip ratio and waist-height ratio) were significantly genetically correlated (genetic correlation coefficients: 0.45, 0.55 and 0.44, respectively) with the liability of incident Type 2 diabetes. We did not observe such a correlation for BMI.Waist circumference as a predictor of future Type 2 diabetes is supported by the finding that they share common genetic influences.

SUBMITTER: Mamtani M

PROVIDER: S-EPMC3849209 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Waist circumference is genetically correlated with incident Type 2 diabetes in Mexican-American families.

Mamtani M M Kulkarni H H Dyer T D TD Almasy L L Mahaney M C MC Duggirala R R Comuzzie A G AG Blangero J J Curran J E JE

Diabetic medicine : a journal of the British Diabetic Association 20130713 1

<h4>Aims</h4>We aimed to determine the genetic and environmental correlation between various anthropometric indexes and incident Type 2 diabetes with a focus on waist circumference.<h4>Methods</h4>We used the data on extended Mexican-American families (808 subjects, 7617.92 person-years follow-up) from the San Antonio Family Heart Study and estimated the genetic and environmental correlations of 16 anthropometric indexes with the genetic liability of incident Type 2 diabetes. We performed bivari ...[more]

PMID: 23796311

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Project description:There is growing interest in the hypertriglyceridemic waist (HTGW) phenotype, defined as high waist circumference (?95 cm in males and ?80 cm in females) combined with high serum triglyceride concentration (?2.0 mmol/L in males and ?1.5 mmol/L in females) as a marker of type 2 diabetes (T2D) and cardiovascular disease. However, the prevalence of this phenotype in high-risk populations, its association with T2D, and the genetic or epigenetic influences on HTGW are not well explored. Using data from large, extended families of Mexican Americans (a high-risk minority population in the USA) we aimed to: (1) estimate the prevalence of this phenotype, (2) test its association with T2D and related traits, and (3) dissect out the genetic and epigenetic associations with this phenotype using genome-wide and epigenome-wide studies, respectively.Data for this study was from 850 Mexican American participants (representing 39 families) recruited under the ongoing San Antonio Family Heart Study, 26 % of these individuals had HTGW. This phenotype was significantly heritable (h (2) r?=?0.52, p?=?1.1?×?10(-5)) and independently associated with T2D as well as fasting glucose levels and insulin resistance. We conducted genome-wide association analyses using 759,809 single nucleotide polymorphisms (SNPs) and epigenome-wide association analyses using 457,331 CpG sites. There was no evidence of any SNP associated with HTGW at the genome-wide level but two CpG sites (cg00574958 and cg17058475) in CPT1A and one CpG site (cg06500161) in ABCG1 were significantly associated with HTGW and remained significant after adjusting for the closely related components of metabolic syndrome. CPT1A holds a cardinal position in the metabolism of long-chain fatty acids while ABCG1 plays a role in triglyceride metabolism.Our results reemphasize the value of HTGW as a marker of T2D. This phenotype shows association with DNA methylation within CPT1A and ABCG1, genes involved in fatty acid and triglyceride metabolism. Our results underscore the importance of epigenetics in a clinically informative phenotype.

Dataset Information

Waist circumference is genetically correlated with incident Type 2 diabetes in Mexican-American families.

Publications

Waist circumference is genetically correlated with incident Type 2 diabetes in Mexican-American families.

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