Ontology highlight
ABSTRACT:
SUBMITTER: Varughese LR
PROVIDER: S-EPMC5754135 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Varughese Lesley R LR Rajpoot Meenakshi M Goyal Soniya S Mehra Ravinder R Chhokar Vinod V Beniwal Vikas V
PloS one 20180104 1
Mutations in gyrA are the primary cause of quinolone resistance encountered in gram-negative clinical isolates. The prospect of this work was to analyze the role of gyrA mutations in eliciting high quinolone resistance in uropathogenic E.coli (UPEC) through molecular docking studies. Quinolone susceptibility testing of 18 E.coli strains isolated from UTI patients revealed unusually high resistance level to all the quinolones used; especially norfloxacin and ciprofloxacin. The QRDR of gyrA was am ...[more]