Ontology highlight
ABSTRACT:
SUBMITTER: Goldberg GW
PROVIDER: S-EPMC5754349 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Goldberg Gregory W GW McMillan Elizabeth A EA Varble Andrew A Modell Joshua W JW Samai Poulami P Jiang Wenyan W Marraffini Luciano A LA
Nature communications 20180104 1
CRISPR-Cas systems offer an immune mechanism through which prokaryotic hosts can acquire heritable resistance to genetic parasites, including temperate phages. Co-transcriptional DNA and RNA targeting by type III-A CRISPR-Cas systems restricts temperate phage lytic infections while allowing lysogenic infections to be tolerated under conditions where the prophage targets are transcriptionally repressed. However, long-term consequences of this phenomenon have not been explored. Here we show that m ...[more]