The Emerging Neurobiology of Bipolar Disorder.
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ABSTRACT:
SUBMITTER: Harrison PJ
PROVIDER: S-EPMC5755726 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
The Emerging Neurobiology of Bipolar Disorder.
Harrison Paul J PJ Geddes John R JR Tunbridge Elizabeth M EM
Trends in neurosciences 20171120 1
Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown, and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium channels as part of the disease process and as a drug target. Second, facilitated by new technologies, it is increasingly apparent that the bipolar phenotype is more complex and nuanced than simply one of recurring manic and de ...[more]
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