Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC5756112 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Kim Jeongkyu J Sturgill David D Sebastian Robin R Khurana Simran S Tran Andy D AD Edwards Garrett B GB Kruswick Alex A Burkett Sandra S Hosogane Eri K EK Hannon William W WW Weyemi Urbain U Bonner William M WM Luger Karolin K Oberdoerffer Philipp P
Molecular cell 20171214 1
Recent integrative epigenome analyses highlight the importance of functionally distinct chromatin states for accurate cell function. How these states are established and maintained is a matter of intense investigation. Here, we present evidence for DNA damage as an unexpected means to shape a protective chromatin environment at regions of recurrent replication stress (RS). Upon aberrant fork stalling, DNA damage signaling and concomitant H2AX phosphorylation coordinate the FACT-dependent deposit ...[more]