Ontology highlight
ABSTRACT:
SUBMITTER: Vincent JA
PROVIDER: S-EPMC2678716 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20080413 5
The eukaryotic DNA replication machinery must traverse every nucleosome in the genome during S phase. As nucleosomes are generally inhibitory to DNA-dependent processes, chromatin structure must undergo extensive reorganization to facilitate DNA synthesis. However, the identity of chromatin-remodeling factors involved in replication and how they affect DNA synthesis is largely unknown. Here we show that two highly conserved ATP-dependent chromatin-remodeling complexes in Saccharomyces cerevisiae ...[more]