Ontology highlight
ABSTRACT:
SUBMITTER: Han P
PROVIDER: S-EPMC5757134 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Han Peng P Qin Zhiqiang Z Tang Jingyuan J Xu Zhen Z Li Ran R Jiang Xuping X Yang Chengdi C Xing Qianwei Q Qi Xiaokang X Tang Min M Zhang Jiexiu J Shen Baixin B Wang Wei W Qin Chao C Zhang Wei W
Oxidative medicine and cellular longevity 20171224
Acute kidney injury (AKI) induced by ischemia-reperfusion is a critical conundrum in many clinical settings. Here, this study aimed to determine whether and how RTA-408, a novel oleanane triterpenoid, could confer protection against renal ischemia-reperfusion injury (IRI) in male mice. Mice treated with RTA-408 undergoing unilateral ischemia followed by contralateral nephrectomy had improved renal function and histological outcome, as well as decreased apoptosis, ROS production, and oxidative in ...[more]