Ontology highlight
ABSTRACT:
SUBMITTER: Hariri H
PROVIDER: S-EPMC5757283 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Hariri Hanaa H Rogers Sean S Ugrankar Rupali R Liu Yang Lydia YL Feathers J Ryan JR Henne W Mike WM
EMBO reports 20171116 1
Eukaryotic cells store lipids in cytosolic organelles known as lipid droplets (LDs). Lipid droplet bud from the endoplasmic reticulum (ER), and may be harvested by the vacuole for energy during prolonged periods of starvation. How cells spatially coordinate LD production is poorly understood. Here, we demonstrate that yeast ER-vacuole contact sites (NVJs) physically expand in response to metabolic stress, and serve as sites for LD production. NVJ tether Mdm1 demarcates sites of LD budding, and i ...[more]