Ontology highlight
ABSTRACT:
SUBMITTER: Gersch M
PROVIDER: S-EPMC5757785 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Gersch Malte M Gladkova Christina C Schubert Alexander F AF Michel Martin A MA Maslen Sarah S Komander David D
Nature structural & molecular biology 20170925 11
Damaged mitochondria undergo mitophagy, a specialized form of autophagy that is initiated by the protein kinase PINK1 and the ubiquitin E3 ligase Parkin. Ubiquitin-specific protease USP30 antagonizes Parkin-mediated ubiquitination events on mitochondria and is a key negative regulator of mitophagy. Parkin and USP30 both show a preference for assembly or disassembly, respectively, of Lys6-linked polyubiquitin, a chain type that has not been well studied. Here we report crystal structures of human ...[more]