Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura N
PROVIDER: S-EPMC2366858 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Nakamura Nobuhiro N Hirose Shigehisa S
Molecular biology of the cell 20080220 5
Recent studies have suggested that ubiquitination of mitochondrial proteins participates in regulating mitochondrial dynamics in mammalian cells, but it is unclear whether deubiquitination is involved in this process. Here, we identify human ubiquitin-specific protease 30 (USP30) as a deubiquitinating enzyme that is embedded in the mitochondrial outer membrane. Depletion of USP30 expression by RNA interference induced elongated and interconnected mitochondria, depending on the activities of the ...[more]