Ontology highlight
ABSTRACT:
SUBMITTER: Zhang M
PROVIDER: S-EPMC5758538 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Zhang Meiqiongzi M Heldin Angelos A Palomar-Siles Mireia M Öhlin Susanne S Bykov Vladimir J N VJN Wiman Klas G KG
Frontiers in oncology 20180104
The tumor suppressor gene <i>TP53</i> is inactivated by mutation in a large fraction of human tumors. Around 10% of <i>TP53</i> mutations are nonsense mutations that lead to premature termination of translation and expression of truncated unstable and non-functional p53 protein. Aminoglycosides G418 (geneticin) and gentamicin have been shown to induce translational readthrough and expression of full-length p53. However, aminoglycosides have severe side effects that limit their clinical use. Here ...[more]