Ontology highlight
ABSTRACT:
SUBMITTER: Fiore D
PROVIDER: S-EPMC5758598 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Fiore Donatella D Ramesh Prashanthi P Proto Maria C MC Piscopo Chiara C Franceschelli Silvia S Anzelmo Serena S Medema Jan P JP Bifulco Maurizio M Gazzerro Patrizia P
Frontiers in pharmacology 20180104
Colorectal cancer (CRC), like other tumor types, is a highly heterogeneous disease. Within the tumor bulk, intra-tumoral heterogeneity is also ascribable to Cancer Stem Cells (CSCs) subpopulation, characterized by high chemoresistance and the unique ability to retain tumorigenic potential, thus associated to tumor recurrence. High dynamic plasticity of CSCs, makes the development of winning therapeutic strategies even more complex to completely eradicate tumor fuel. Rimonabant, originally synthe ...[more]