Toxicity Assessment of SiO2 and TiO2 in Normal Colon Cells, In Vivo and in Human Colon Organoids.
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ABSTRACT:
SUBMITTER: Park SB
PROVIDER: S-EPMC7464288 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Toxicity Assessment of SiO<sub>2</sub> and TiO<sub>2</sub> in Normal Colon Cells, In Vivo and in Human Colon Organoids.
Park Sung Bum SB Jung Won Hoon WH Kim Ki Young KY Koh Byumseok B
Molecules (Basel, Switzerland) 20200807 16
We conducted systemic assessments on the toxicity of silicon dioxide (SiO<sub>2</sub>) and titanium dioxide (TiO<sub>2</sub>) nanoparticles using different forms of normal colon cells (CCD-18Co), in vivo and in human colon organoids. The in vivo acute oral toxicity data showed that the LD<sub>50</sub> values are greater than 2000 mg/kg for both the SiO<sub>2</sub> and TiO<sub>2</sub> nanoparticles; however, the SiO<sub>2</sub> and TiO<sub>2</sub> nanoparticles induced cytotoxicity in two-dimensi ...[more]
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