Ontology highlight
ABSTRACT:
SUBMITTER: Dulin JN
PROVIDER: S-EPMC5758751 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Dulin Jennifer N JN Adler Andrew F AF Kumamaru Hiromi H Poplawski Gunnar H D GHD Lee-Kubli Corinne C Strobl Hans H Gibbs Daniel D Kadoya Ken K Fawcett James W JW Lu Paul P Tuszynski Mark H MH
Nature communications 20180108 1
Neural progenitor cell (NPC) transplantation has high therapeutic potential in neurological disorders. Functional restoration may depend on the formation of reciprocal connections between host and graft. While it has been reported that axons extending out of neural grafts in the brain form contacts onto phenotypically appropriate host target regions, it is not known whether adult, injured host axons regenerating into NPC grafts also form appropriate connections. We report that spinal cord NPCs g ...[more]