Ontology highlight
ABSTRACT:
SUBMITTER: Font-Burgada J
PROVIDER: S-EPMC4545590 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Font-Burgada Joan J Shalapour Shabnam S Ramaswamy Suvasini S Hsueh Brian B Rossell David D Umemura Atsushi A Taniguchi Koji K Nakagawa Hayato H Valasek Mark A MA Ye Li L Kopp Janel L JL Sander Maike M Carter Hannah H Deisseroth Karl K Verma Inder M IM Karin Michael M
Cell 20150801 4
Compensatory proliferation triggered by hepatocyte loss is required for liver regeneration and maintenance but also promotes development of hepatocellular carcinoma (HCC). Despite extensive investigation, the cells responsible for hepatocyte restoration or HCC development remain poorly characterized. We used genetic lineage tracing to identify cells responsible for hepatocyte replenishment following chronic liver injury and queried their roles in three distinct HCC models. We found that a pre-ex ...[more]