Ontology highlight
ABSTRACT:
SUBMITTER: Jacobs A
PROVIDER: S-EPMC5758871 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Jacobs Alexander A Hoover Haley H Smith Edward E Clemmer David E DE Kim Chul-Hyun CH Kao C Cheng CC
Nucleic acids research 20180101 1
In the brome mosaic virus (BMV) virion, the coat protein (CP) selectively contacts the RNA motifs that regulate translation and RNA replication (Hoover et al., 2016. J. Virol. 90, 7748). We hypothesize that the unstructured N-terminal arm (NTA) of the BMV CP can specifically recognize RNA motifs. Using ion mobility spectrometry-mass spectrometry, we demonstrate that peptides containing the NTA of the CP were found to preferentially bind to an RNA hairpin motif that directs the initiation of BMV ...[more]