A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Huang KL
PROVIDER: S-EPMC5759334 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.
Huang Kuan-Lin KL Marcora Edoardo E Pimenova Anna A AA Di Narzo Antonio F AF Kapoor Manav M Jin Sheng Chih SC Harari Oscar O Bertelsen Sarah S Fairfax Benjamin P BP Czajkowski Jake J Chouraki Vincent V Grenier-Boley Benjamin B Bellenguez Céline C Deming Yuetiva Y McKenzie Andrew A Raj Towfique T Renton Alan E AE Budde John J Smith Albert A Fitzpatrick Annette A Bis Joshua C JC DeStefano Anita A Adams Hieab H H HHH Ikram M Arfan MA van der Lee Sven S Del-Aguila Jorge L JL Fernandez Maria Victoria MV Ibañez Laura L Sims Rebecca R Escott-Price Valentina V Mayeux Richard R Haines Jonathan L JL Farrer Lindsay A LA Pericak-Vance Margaret A MA Lambert Jean Charles JC van Duijn Cornelia C Launer Lenore L Seshadri Sudha S Williams Julie J Amouyel Philippe P Schellenberg Gerard D GD Zhang Bin B Borecki Ingrid I Kauwe John S K JSK Cruchaga Carlos C Hao Ke K Goate Alison M AM
Nature neuroscience 20170619 8
A genome-wide survival analysis of 14,406 Alzheimer's disease (AD) cases and 25,849 controls identified eight previously reported AD risk loci and 14 novel loci associated with age at onset. Linkage disequilibrium score regression of 220 cell types implicated the regulation of myeloid gene expression in AD risk. The minor allele of rs1057233 (G), within the previously reported CELF1 AD risk locus, showed association with delayed AD onset and lower expression of SPI1 in monocytes and macrophages. ...[more]
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