Ontology highlight
ABSTRACT:
SUBMITTER: Westfall S
PROVIDER: S-EPMC6476497 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Westfall Susan S Lomis Nikita N Prakash Satya S
PloS one 20190422 4
The gut-brain-axis (GBA) describing the bidirectional communication between the gut microbiota and brain was recently implicated in Alzheimer's disease (AD). The current study describes a novel synbiotic containing three metabolically active probiotics and a novel polyphenol-rich prebiotic which has beneficial impacts on the onset and progression of AD. In a transgenic humanized Drosophila melanogaster model of AD, the synbiotic increased survivability and motility and rescued amyloid beta depos ...[more]