Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC5759774 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Wu Jie J Zhang Hedong H Shi Xiaomin X Xiao Xiang X Fan Yihui Y Minze Laurie J LJ Wang Jin J Ghobrial Rafik M RM Xia Jiahong J Sciammas Roger R Li Xian C XC Chen Wenhao W
Immunity 20171205 6
CD4<sup>+</sup> T cells orchestrate immune responses and destruction of allogeneic organ transplants, but how this process is regulated on a transcriptional level remains unclear. Here, we demonstrated that interferon regulatory factor 4 (IRF4) was a key transcriptional determinant controlling T cell responses during transplantation. IRF4 deletion in mice resulted in progressive establishment of CD4<sup>+</sup> T cell dysfunction and long-term allograft survival. Mechanistically, IRF4 repressed ...[more]